Sakura has one sibling, her 17-year old brother Toya Kinomoto. He has magical powers, however, unlike Sakura, his manifest themselves with him seeing ghosts and being aware of magical beings, but also having a "sixth sense" for detecting impending threats.

Sakura's father, Fujitaka Kinomoto is a college professor of archaeology at Towa University. He's extremely kind and caring, and although he's very busy with his work, he finds time for his children whenever he can. Her mother, Nadeshiko Kinomoto sadly died when Sakura was only 3. She was exceptionally beautiful and used to work as a model. In the series Nadeshiko is sometimes seen as an angel, although only Toya is able to see her.

Sakura's best friend Tomoyo Daidouji designs and creates the cute outfits that Sakura wears while capturing cards. She also makes sure to record any special event with her video camera. Tomoyo's mother, Sonomi Daidouji, is the president of a big toy company, but also the cousin of Nadeshiko.

Early on, Syaoran Li joins the class. Being a distant relative of Clow Reed, the creator of the Clow cards, he is sent to Sakura's city by his family to start collecting the cards.

Yukito Tsukishiro is Toya's best friend and Sakura's big crush. He is very kind and gentle and is hardly ever seen without a smile. We slowly learn during the first arc that there is more to him than meets the eye.

Halfway during the first arc, Kaho Mizuki joins Sakura's school as a substitute math teacher. She remains a kind and mysterious person throughout the arc.

During the second arc, Eriol Hiiragizawa joins Sakura's class. He creates a series of "magical disasters" in order to force Sakura to convert the Clow cards into her own Sakura cards. Eriol is helped in this by his own two Guardians: Spinel Sun being the counterpart of Kero and Ruby Moon being the counterpart of Yue.